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pentobarbital will lessen the level or effect of elbasvir/grazoprevir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. The therapeutic influence of elbasvir/grazoprevir might be diminished if coadministered with solid CYP3A inducers which is therefore contraindicated.pentobarbital will decrease the level or effect of felod